Sp1 collagen I A1 polymorphism in women with stress urinary incontinence
Ημερομηνία δημοσίευσης :
Introduction and hypothesis: Stress urinary incontinence (SUI) is in part attributed to qualitative and quantitative changes in connective tissue of the urogenital tract. We examined the association of collagen type I a1 (COLIA 1)
Sp1 polymorphism with the risk of SUI. Methods: Forty-five postmenopausal women suffering from urodynamically verified SUI (study group) were compared
to 45 healthy volunteers (control). DNA was extracted from peripheral blood. The genotyping concerning the type 1 a1 collagen gene Sp1 polymorphism was performed with polymerase chain reaction. Results: The polymorphic T allele was overrepresented in the SUI patients (63.2% versus 36.8%, p=0.016). Odds
ratio for SUI in women harboring the T allele was 2.19 (95% CI 1.149–4.176) compared to women with the wildtype genotype.
